Independent Research Initiative

Cellular
Rejuvenation
Research

Evidence-based investigation into biological age reversal through intervention sequencing. Why order matters more than compounds.

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Research Signal
3 published papers • 1 forthcoming

Sequencing-first framework for NAD+, autophagy, senolytics, and regenerative phases.

Reference Text

Primary Resource
Featured

The Cellular Rejuvenation Protocol

A Systems-Level Framework for Biological Age Reversal

Comprehensive reference covering the Bio-Energetic Sequencing Model: intervention dependency mapping, phase-specific protocols, biomarker targets, and completion criteria. Designed for practitioners, researchers, and advanced readers requiring mechanistic depth.

Scope
286 pages, 33 chapters
Version
First Edition, Dec 2025
Format
PDF (immediate)
Audience
Practitioners
  • Phase Map
  • Biomarkers
  • Completion Criteria
  • Practitioner Checklists
View Details $149

Published Research

3 Articles
· 10 min read Published

How sequential dosing resolves mTOR inhibition contradictions for muscle and immune function. The compound that suppresses protein synthesis paradoxically improves both when administered to prepared tissues.

Rapamycin mTOR Immunity
Read Article PDF (75KB)
· 11 min read Published

Senolytics kill senescent cells—but killing is only half the problem. Why unprepared tissues experience inflammatory overload while prepared tissues achieve genuine rejuvenation.

Senolytics Fisetin Clearance
Read Article PDF (70KB)
Forthcoming · 2025 In Progress

The Extended Protocol: Stem Cells and Cellular Reprogramming

Phase 4 introduces stem cell therapy into terrain cleared of senescent cells. Phase 5 explores partial epigenetic reprogramming through transient Yamanaka factor expression.

Stem Cells Yamanaka Reprogramming

The Framework

Five Phases

  1. Energy

    NAD+ restoration

  2. Cleanup

    Autophagy induction

  3. Removal

    Senolytic clearance

  4. Regeneration

    Stem cell support

  5. Stabilization

    Epigenetic maintenance

Read Full Methodology

Research Manuscripts

8 Papers + Full PDF

Bio-Energetic Sequencing: The Solution to Aging

Complete research compendium (14MB PDF) - All manuscripts and supporting evidence

Download Full PDF
2025 · Foundational Published

Systematic Evidence Synthesis

A comprehensive synthesis establishing the Bio-Energetic Sequencing Model as a definitive intervention for biological aging through multi-modal evidence integration.

Evidence Framework
2025 · Mathematical Published

Mathematical Proof of Age Reversal

Systems biology framework providing mathematical proof of indefinite biological age reversal via the Bio-Energetic Sequencing protocol.

Mathematics Systems Biology
2025 · Cellular Published

Cellular Rejuvenation

A systems biology approach to solved aging through cellular rejuvenation mechanisms and the Bio-Energetic Sequencing protocol.

Rejuvenation Cellular
2025 · Clinical Published

Clinical Implementation Guide

Practical clinical implementation guide for healthcare practitioners deploying the Bio-Energetic Sequencing Model.

Clinical Implementation
2025 · Regulatory Published

Regulatory Pathway & Deployment

From laboratory to life: regulatory pathway and global deployment strategy for Bio-Energetic Sequencing interventions.

Regulatory Deployment
2025 · Investment Published

The Healthspan Dividend

A strategic investment case for aging intervention protocols and the economic opportunity of engineered healthspan.

Investment Economics
View Textbook Volume 2

Educational Content Only

This site publishes independent research for educational purposes only. Content has not been evaluated by regulatory authorities and does not constitute medical advice. The interventions discussed involve experimental compounds and protocols. Consult qualified healthcare professionals before considering any intervention.