The Bio-Energetic Sequencing Model
A dependency-gated protocol for systemic age reversal. The order of interventions matters as much as the interventions themselves.
NAD+ → ENABLES → Sirtuins → ACTIVATES → Autophagy → CLEARS → Senescent Cells → ENABLES → Stem Cell Regeneration
The Five Phases
Energy Restoration
NAD+ is the master regulator of cellular energy. Without adequate NAD+ levels, downstream processes like autophagy cannot function optimally.
NAD+ enables [Sirtuins]
Cellular Cleanup
Autophagy clears damaged proteins and organelles. This process is energy-dependent and must follow NAD+ restoration.
Autophagy inhibited by [mTOR]
Autophagy decreases [senescent_cells, protein_aggregates]
Senescent Cell Removal
Senolytics selectively clear zombie cells that resist apoptosis. Most effective after autophagy has cleared cellular debris.
Senolytics belong to [Phase 3]
Stem Cell Reset
With senescent cells cleared, the stem cell niche can be optimized for regeneration using growth factors and signaling modulators.
Epigenetic Optimization
The final phase addresses methylation patterns and epigenetic age. Rapamycin and other mTOR modulators are introduced here.
Molecular Dependency Map
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Engineered Healthspan is commercializing the Bio-Energetic Sequencing Model through clinical protocols, digital therapeutics, and supplement formulations.
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